Particle Size Analyzer - Mastersizer 2000

The Mastersizer 2000 applies advanced technologies to the process of particle size analysis

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	21 CFR Part 11
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Mastersizer 2000


"Routine use of Standard Operating Procedures and minimal maintenance requirements associated with the Mastersizer 2000 are essential in plant laboratories. At the same time, however, the flexibility of the Mastersizer 2000 software and its wide measurement range are important in R&D." - OMYA AG

The Mastersizer 2000 particle size analyzer has been developed to meet industry's growing need for global comparability of results, traceability, regulatory compliance, and efficiency in the laboratory. In introducing the Mastersizer 2000 particle size analyzer, Malvern has advanced particle size analysis to the point where it is now a simple, straightforward and routine task.

	Accuracy and Reproducibility Accuracy: ± 1% on the Dv50 using the Malvern Quality Audit Standard. Instrument-to-instrument reproducibility: Better than 1% RSD on the Dv50 using the Malvern Quality Audit Standard.
	Assured reproducibility Software-driven SOPs eliminate user variability and enable global method transfer. All measurement parameters are automatically embedded in the result files and can be critically reviewed by e-mail recipients. Measurements can be replicated by following the same SOP.
	Broad measuring range Measures materials from 0.02µm to 2000µm.
	Wide range of sample types For the measurement of emulsions, suspensions and dry powders.
	Ease of use Fully automated for ease of use. Designed to eliminate user-to-user variability. Reduces training requirements for new users and maximizes deployment of skilled personnel.
	Flexibility Wide range of sample dispersion units. Rapid changeover between sample dispersion units with automatic configuration. "Plug and Play" cassette system allows simultaneous connection of two sample dispersion units.
	Regulatory Compliance Full QSpec validation documentation available including compliance with 21 CFR Part 11.
	User-friendly Software Software-driven Standard Operating Procedures (SOPs) eliminate user variability. An SOP-creation wizard helps users to create good measurement methods. On-line help and advice on every aspect of performing a measurement available at the click of a button. On screen instructions lead user through the measurement process. SOPs supplied for routine sample analyzes. Custom Report Designer allows screen layout and printouts to be configured to suit each user. Custom calculator allows the parameters important to your application to be defined.

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Summary

The key to quality particle size measurement is the ability to present a well-dispersed sample to the instrument optics at an appropriate concentration with a minimum of sample bias. Efficient sample dispersion is essential for achieving optimum measurement. The Mastersizer 2000 user can choose from a variety of sample dispersion units for both wet and dry measurement modes that are designed to meet this requirement in full.

Many materials need to be measured in a wet dispersion. These include materials that are used wet in the manufacturing process, sticky materials such as clay or kaolinite, or materials that have a tendency to agglomerate when dry, such as titanium dioxide.

For materials that are used and produced dry in the manufacturing process, such as cement, powder coatings, pharmaceuticals and micronized powders, dry measurement is preferable.

The Mastersizer 2000 has the flexibility to allow wet and dry measurements to be made in rapid succession, as well as enabling the user to change rapidly from aqueous to solvent based dispersions.

Wet dispersion



		Hydro µP The Hydro µP for use when only the smallest quantities of extremely high value or toxic materials may be available to measure.


		Hydro S The Hydro S small volume general-purpose automated sample dispersion unit.


		Hydro G The Hydro G large volume general-purpose automated sample dispersion unit designed for the measurement of larger, denser material.


		Hydro MU The Hydro MU large volume manual sample dispersion unit using standard laboratory beakers as the sample container.


		Hydro SM The Hydro SM manual small volume sample dispersion unit.


		Gateway cell