Viscotek GPC/SEC range

Gel Permeation Chromatography/Size Exclusion Chromatography (GPC/SEC) is the technique of choice for rapid and reliable characterization of molecular weight and molecular structure for all types of macromolecules – proteins, natural polymers and synthetic polymers.

Whether you are looking for a complete system or an additional detector to enhance your existing system, Malvern offers the most comprehensive range of products for all your macromolecular GPC/SEC characterisation needs.  At the heart of this range are the Viscotek advanced GPC/SEC systems, including the powerful TDAmax system with OmniSEC software.

Explore the three complete systems below. If you need help in configuring a custom system to meet your application needs, simply click on contact us and one of our Application Specialists will assist you.

Proteins Absolute molecular weight Oligomeric composition and aggregation Protein size and density Conjugate composition Second virial coefficient

Polymers Absolute molecular weight Molecular weight distribution Branching and structure Molecular size Copolymer composition

GPC/SEC Systems:

		Viscotek TDAmax - Integrated, temperature controlled GPC/SEC system The Viscotek TDAmax is a complete, temperature controlled, advanced, multidetector GPC/SEC system suitable for all macromolecular applications, particularly research.  It consists of three unique and complementary components – The Triple or Tetra Detector Array (TDA), the GPCmax integrated solvent and sample delivery module and the OmniSEC software.
		Viscotek 270max - Modular, ambient temperature GPC/SEC system The Viscotek 270max is a modular advanced multi detector detector system that operates at ambient temperature.  It is perfect for the routine full characterization of natural and synthetic polymers, copolymers and proteins.
		Viscotek RImax - Modular, conventional GPC/SEC system The Viscotek RImax is a modular, conventional calibration system.  It offers simple operation and full upgradeability to advanced detection.  Designed for routine GPC/SEC and teaching purposes.  Operates with the same powerful OmniSEC software as used in the advanced systems.

High temperature system for polyolefin analysis:

		Viscotek HT-GPC - For polyolefin analysis The Viscotek HT-GPC is a modular high temperature GPC system designed specifically and exclusively for the characterization of polyolefins at up to 160°C.

What's Next?

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More information

	Featured presentations and application notes:
	Application communication: Protein and polymer molecular size by GPC/SEC The main goal of most Gel Permeation/Size Exclusion Chromatography (GPC/SEC) experiments is to determine the molecular weight distribution (MWD) of the sample or compare molecular weights (MW) of several samples.
	Application communication: Universal calibration to study star-branched polystyrene It is shown in this application communication that the number of branches of a star polymer can be assessed by merely adding a viscometer detector to a conventional chromatography system.
	Application communication: Determination of polymer structure by GPC It is advantageous to use light scattering to determine molecular weights provided the signals are sufficiently intensive strong. Triple detection combines these detection capabilities into a single system to give molecular weight and structure without limitations.
	Application communication: Structural differences in modified starches The Viscotek triple detection system provides a convenient and rapid way to characterize starches and modified starches. The instrument allows determination of molecular weight and molecular size in a single run using normal conditions and sample concentrations. The IV and size data allow differentiation between molecules of differing structures. The technique is equally applicable to other polysaccharides and all other synthetic or natural polymers such as proteins and DNA.
	Application communication: Characterization of branched copolymers by triple detection GPC Polymers can be loosely grouped into two structural categories – linear and branched. A linear polymer is composed of a single main chain of repeating units, linked in a regular end to tail fashion.
	Application communication: Characterization of modified phenolic resins The triple detection chromatography technique was shown to be able to detect the modification of the phenolic resins. The high molecular weight is easily revealed in the light scattering signal while the viscometer gives information on the partial molar volume occupied by the polymer.
	Application Note: SELS – Solvent Enhanced Light Scattering Viscotek has been a strong advocate of good chromatography as a prerequisite for GPC (Gel Permeation Chromatography) data accuracy. Our recent work in application development has been driven by extremely difficult samples from industrial, biopharmaceutical and academic sources.
	Application Note: Solvent Enhanced Light Scattering (SELS) of Fluoro-Polyester Traditionally in GPC, the sample dissolution solvent and the mobile phase are one and the same. However, a closer look at the demands of sample solvent and mobile phase suggests that this should not always be the case.
	Application Note: Conjugated polymer analysis by GPC - PDA Traditionally in GPC, the sample dissolution solvent and the mobile phase are one and the same. However, a closer look at the demands of sample solvent and mobile phase suggests that this should not always be the case.
	Application Note: Calcium-induced hydrodynamic changes of the RTX region of the adenylate cyclase toxin from Bordetella pertussis by SEC-TDA In this note, we show that size exclusion chromatography followed by triple detection array (SEC-TDA) is an appropriate method to investigate the hydrodynamic and conformational changes of polypeptides.
	Application Note: Characterization of chitosan from various sources This note proves that the use of conventional viscometric measurements of chitosan to estimate the molecular weight using Ubbelhode-type viscometer are flawed as the M-H curve exhibits a curvature. However, the Viscotek triple detector was used to study successfully the molecular weight and conformation of chitosan.
	On-demand presentation: Basic Triple Detection Chromatography Size Exclusion Chromatography (SEC), also called Gel Permeation Chromatography (GPC) is a separation technique used to analyze the molecular weight and molecular weight distribution. The technique is used extensively for synthetic polymers characterization. Aqueous chromatography is trickier due to the electrostatic interaction in between the column packing material and the sample to be separated. Triple detection allows for absolute measurements of the molecular weights and distribution without column calibration, alleviating the problems caused by electrostatic interaction.
	On-demand presentation: Polysaccharide characterization by triple detection Triple detection is used with size-exclusion chromatography to characterize polymer distributions. Polysaccharides are natural polymers that can be measured using this technique. Use of triple detection allows molecular weight, size and concentration of polysaccharides to be determined and also giving information about structure. This webinar will describe the technique and provide some application examples.
	On-demand presentation: Protein characterization by triple detection Triple detection is used with size-exclusion chromatography to separate and characterize molecules such as proteins. Using triple detection allows the molecular weight and molecular size of a protein to be calculated independently of each other and retention time. This webinar will describe the technique and provide some example application data.
	On-demand presentation: Quality Control Analysis of CPVC Pipe Using Advanced Detection GPC Chlorinated polyvinylchloride (CPVC) is a common thermoplastic used for applications requiring an economical material for liquid handling. The process of manufacturing CPVC pipe follows two basic steps. The material is first compounded with a variety of additives to control both functional an aesthetic properties and is then extruded under heat and pressure to mold the final product. In some cases, the final product does not contain the required physical properties. The material’s performance can be directly linked to the structural deficiencies of the CPVC. To monitor these changes, the CPVC can be isolated, separated by GPC, and analyzed using advanced detection to determine inconsistencies in the structural properties that may arise during the extrusion process. These changes, whether they are structural or chemical, can be correlated back to the stability of the virgin CPVC used, preventing further processing of defective material
	More application notes and online presentations are available to search for FREE in the Malvern Application Library and Presentations Database (Requires Free registration).