Zetasizer Nano Z

Overview

The Zetasizer Nano Z is the perfect system for measuring zeta potential and electrophoretic mobility, when the measurement of size or molecular weight is not required.

• Zeta potential of proteins and particles from 3.8nm up to 100 microns (diameter) using patented M3-PALS technology
• A Quality Factor gives confidence in the data
• The Expert advice report gives help to improve sample preparation or the measurement procedure
• 21CFR part 11 software option enables compliance with ER/ES
• Research software option gives access to further features and analysis algorithms for the light scattering specialist
• Automation of measurements using an autotitrator option
• Optical filter option to improve measurements with fluorescent sample

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How it works

The Zetasizer Nano Z uses micro-electrophoresis / electrophoretic light scattering technology to measure zeta potential and electrophoretic mobility.

Laser Doppler Micro-electrophoresis is the technique used to measure zeta potential. An electric field is applied to a solution of molecules or a dispersion of particles, which will then move with a velocity related to their zeta potential. This velocity is measured using a patented laser interferometric technique called M3-PALS (Phase analysis Light Scattering). This enables the calculation of electrophoretic mobility, and from this the zeta potential for the accurate measurement of a wide range of sample types and dispersion media including high salt concentrations and non-aqueous dispersants.

Software
The software is designed to be versatile and rich in features without compromising ease of use. Standard Operating Procedures (SOP) simplify routine measurements, a quality factor gives a single place to look for the success of a measurement, and expert advice is given to assist with data interpretation.

Options
The MPT-2 Autotitrator enables the study of the effect of changes in pH, conductivity, or any additive to be automated.
A range of disposable and reusable cells are available to optimise the measurement in terms of sample volume, concentration and flow measurement.

Other options include filters to improve the measurement of fluorescent samples, a temperature range extension to 120ºC and a Viscometer to determine the sample viscosity to the accuracy required for the techniques used.

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Specification

Zeta potential

Parameter

Specification

Measurement range:

3.8nm – 100 microns*

Measurement principle:

Electrophoretic Light Scattering

Minimum sample volume:

150µL

Accuracy:

0.12µm.cm/V.s for aqueous systems using
NIST SRM1980 standard reference material

Patents granted:

M3, Mixed mode measurement
UK 2361772, EP1154266, US7217350, JP2002005888

Temperature control range:

0ºC - 90ºC +/-0.1**, 120ºC option

Light Source:

He-Ne laser 633nm, Max 5mW

Laser safety:

Class 1

Power: (V, Hz, VA)

100VA

Weight and dimensions:

Parameter

Specification

Dimensions (W, D, H)

320mm, 600mm, 260mm (W,D,H)

Weight: (kg)

21

Operating environment:

Parameter

Specification

Temperature:

15°C – 40°C

Humidity:

35% - 80% non-condensing

Operating platforms:

Parameter

Specification

Operating platforms:

Windows XP, VISTA, Windows 7
(compatible only with 32 bit versions of
Windows XP Pro and Windows 7)

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Accessories

A range of accessories are available to make life easier, or to add capability to the system

Factory fitted options

Narrow band filters

Useful where the sample fluoresces. Will select the scattering from non-fluorescing particles and improve the signal to background ratio

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